Can physiologic colonic [ 18 F]FDG uptake in PET/CT imaging predict response to immunotherapy in metastatic melanoma?

Christos SachpekidisChristoph K Stein-ThoeringerAnnette Kopp-SchneiderVivienn WeruAntonia Dimitrakopoulou-StraussJessica C Hassel

Published in: European journal of nuclear medicine and molecular imaging (2023)

F]FDG uptake in PET/CT, as assessed by means of SUV, before start of ipilimumab-based treatment does not seem to independently predict patient survival of metastatic melanoma. On the other hand, volumetric PET parameters, such as MTV and TLG, derived from the normal gut may identify patients showing disease control to immunotherapy and significantly correlate with PFS. Moreover, the investigation of glucose metabolism in the spleen and the bone marrow may offer prognostic information.

Keyphrases

pet ct
bone marrow
positron emission tomography
end stage renal disease
newly diagnosed
ejection fraction
high resolution
mesenchymal stem cells
prognostic factors
case report
healthcare
computed tomography
mass spectrometry
combination therapy
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