Deoxyribonuclease activity negative correlates with extracellular DNA in uncomplicated singleton pregnancies in the third trimester.

Barbora VlkováĽubica JanovičováPetra PšenkováLívia MelníkováBarbora BalažovjechováJozef ZáhumenskýPeter Celec

Published in: Journal of perinatal medicine (2021)

The role of plasma ecDNA of fetal and maternal origin is studied in the pathogenesis of pregnancy-complications. The results indicate that plasma DNase activity could negatively regulate ecDNA concentrations and should, thus, be analyzed in preeclampsia, preterm birth and other ecDNA-related pregnancy complications.

Keyphrases

preterm birth
gestational age
low birth weight
birth weight
pregnancy outcomes
risk factors
single molecule
early onset
cell free
pregnant women
urinary tract infection
body mass index