Targeting EGFR Enriches Stem Cell-Like Properties in Salivary Adenoid Cystic Carcinoma by Activating the Notch1 Pathway.

Yang WangYong HanShengming XuLing ZhangXiangkai ZhangJiong DengWeimin YeShuli Liu

Published in: Cancer management and research (2020)

Our results provide an explanation for the worsened survival observed in some studies of erlotinib therapy in SACC and provide potential therapeutic strategies by combined blockade of the EGFR and Notch1 pathways.

Keyphrases

epidermal growth factor receptor
small cell lung cancer
stem cells
tyrosine kinase
advanced non small cell lung cancer
cell proliferation
signaling pathway
cancer therapy
case control
free survival
cell therapy
human health
drug delivery
climate change
mesenchymal stem cells
bone marrow
smoking cessation