Blocking the interaction between interleukin-17A and endoplasmic reticulum stress in macrophage attenuates retinal neovascularization in oxygen-induced retinopathy.

Ya'nuo WangShuang GaoSha GaoNa LiBing XieXi Shen

Published in: Cell & bioscience (2021)

The interplay between IL-17A and ER stress contributes to RNV in macrophages via modulation of TXNIP/NLRP3 signaling pathway under hypoxic conditions. The feedback loops may become an innovative and multiple pharmacological therapeutic target for ischemic retinopathy.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
signaling pathway
diabetic retinopathy
nlrp inflammasome
high glucose
optical coherence tomography
diabetic rats
pi k akt
adipose tissue
epithelial mesenchymal transition
endothelial cells
ischemia reperfusion injury
oxidative stress
optic nerve