sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis.

Yingjie ZhaoXuezhi YangSiyu LiBingjie ZhangSusu LiXinwei WangYueye WangChengyan JiaYan ChangWei Wei

Published in: Stem cell research & therapy (2021)

sTNFRII-Fc modification protects MSCs against apoptosis/autophagy induced by TNF-α, in addition to releasing sTNFRII-Fc neutralizing TNF-α to block relevant immune-inflammation cascade, and thus exert better therapeutic effects in alleviating inflammatory arthritis.

Keyphrases

oxidative stress
rheumatoid arthritis
endoplasmic reticulum stress
cell death
mesenchymal stem cells
cell cycle arrest
endothelial cells
umbilical cord
signaling pathway