Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples.

Sinead ToomeyAoife CarrMateusz Janusz MezynskiYasir ElaminShereen RafeeMattia CremonaClare MorganStephen MaddenKhairun I Abdul-JalilKathy GatelyAngela FarrellyElaine W KaySusan KennedyKenneth O'ByrneLiam GroganOscar BreathnachPatrick G MorrisAlexander J EustaceJoanna FayRobert CumminsAnthony O'GradyRoshni KalachandNorma O'DonovanFergal KelleherAine O'ReillyMark DohertyJohn CrownBryan T Hennessy

Published in: Journal of translational medicine (2020)

Hotspot mutational profiling is a sensitive, high-throughput approach for identifying mutations of clinical relevance to molecular based therapeutics for treatment of cancer, and could potentially be of use in identifying novel opportunities for genotype-driven clinical trials.

Keyphrases

high throughput
clinical trial
single cell
papillary thyroid
transcription factor
squamous cell
gene expression
copy number
study protocol
genome wide
replacement therapy