Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis.
Moritz LeppkesAylin LindemannStefanie GößweinSusanne PaulusDominik RothAnne HartungEva LiebingSebastian ZundlerMiguel Gonzalez-AceraJay V PatankarFabrizio MasciaKristina ScheibeMarkus HoffmannStefan UderhardtChristine SchauerSebastian FoerschClemens NeufertMichael ViethGeorg SchettRaja AtreyaAnja A KühlAndre BleichChristoph BeckerMartin HerrmannMarkus Friedrich NeurathPublished in: Gut (2021)
Our findings uncover that neutrophils induce secondary immunothrombosis by PAD4-dependent mechanisms. Insufficient immunothrombosis may favour rectal bleeding in UC.