Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage.

Kshama GuptaRalph B PerkersonTammee M ParsonsRamacharan AngomDanilyn AmernaJeremy D BurgessYingxue RenPamela J McLeanDebabrata MukhopadhyayPrasanna VibhuteZbigniew K WszolekAbba C ZubairAlfredo Quiñones-HinojosaTakahisa Kanekiyo

Published in: Stem cell research & therapy (2024)

The iMSC secretome is a comodulated composite of proangiogenic and immunosuppressive factors that has the potential to alleviate radiation-induced vascular endothelial cell damage and immune activation.

Keyphrases

radiation induced
endothelial cells
radiation therapy
oxidative stress
mesenchymal stem cells
high glucose
risk assessment
bone marrow
climate change