Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia.
Mohammad BadranBisher AbuyassinSaeid GolbidiNajib AyasIsmail LaherPublished in: Oxidative medicine and cellular longevity (2019)
ALA attenuates endothelial dysfunction by preventing oxidative stress and inflammation and restoring nitric oxide bioavailability in mice exposed to CIH. Our data suggests the potential beneficial use of ALA as adjunctive therapy in OSA.
Keyphrases
- oxidative stress
- nitric oxide
- high fat diet induced
- dna damage
- diabetic rats
- ischemia reperfusion injury
- induced apoptosis
- obstructive sleep apnea
- endothelial cells
- hydrogen peroxide
- stem cells
- high intensity
- big data
- nitric oxide synthase
- type diabetes
- wild type
- machine learning
- metabolic syndrome
- heat shock
- bone marrow
- drug induced
- cell therapy
- endoplasmic reticulum stress