Hippocampal place cell and inhibitory neuron activity in disrupted-in-schizophrenia-1 mutant mice: implications for working memory deficits.
Lia Mesbah-OskuiJohn GeorgiouJohn C RoderPublished in: NPJ schizophrenia (2015)
The generalized spatial selectivity of Disc1-L100P place cells suggests a simplification of the ensemble place codes that encode individual locations and subserve spatial working memory. Moreover, these results suggest that deficient working memory in schizophrenia results from an impaired ability to uniquely code the individual components of a memory sequence.
Keyphrases
- working memory
- bipolar disorder
- transcranial direct current stimulation
- attention deficit hyperactivity disorder
- induced apoptosis
- wild type
- traumatic brain injury
- single cell
- cell cycle arrest
- high fat diet induced
- metabolic syndrome
- type diabetes
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- adipose tissue
- convolutional neural network
- skeletal muscle
- blood brain barrier
- structural basis
- cerebral ischemia