Total Synthesis of Kopsone.

Kazutoshi TomoyaKazuaki KomiyaDaisuke NakajimaNariyoshi Umekubo Satoshi Yokoshima

Published in: Organic letters (2023)

A total synthesis of kopsone was achieved, featuring stereoselective preparation of an acyclic aldehyde having a protected hydroxylamine moiety via Ireland-Claisen rearrangement and intramolecular cycloaddition of an eight-membered cyclic nitrone to form the 2-azabicyclo[3.3.1]nonane skeleton.

Keyphrases

molecularly imprinted
energy transfer
quantum dots
solid phase extraction