Hepatocellular Carcinoma in Hepatitis B Virus-Infected Patients and the Role of Hepatitis B Surface Antigen (HBsAg).
Satinder P KaurArslan TalatHamidreza Karimi-SariAndrew GreesHao Wei ChenDaryl T Y LauAndreea M CatanaPublished in: Journal of clinical medicine (2022)
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading cause of cancer-related death worldwide. Hepatitis B virus (HBV) infection is among the main risk factors for HCC. The risk of HCC is not eliminated completely after viral suppression, due to HBV DNA integrated into human chromosomes. Cirrhosis, HBV viral DNA levels, age, male gender, the immune response of the host against HBV, and a combination of obesity and diabetes are among the main risk factors for HCC. Active viral replication and long-standing active disease with inflammation are associated with a higher risk of HCC. Treatment of HBV with nucleos(t)ide analogues (NAs) decreased HCC risk by effectively decreasing viral load and inflammation. Similar risk factors have been reported in hepatitis B patients after seroclearance. Studies have reported decreased risk of HCC after seroclearance, but there were also conflicting results from a few studies indicating no difference in risk of developing HCC. The difference in HCC rates could be because of other factors such as coinfection, occult HBV infection, family history, HBV genotype, and other comorbidities. Due to the persistent risk of HCC after seroclearance, HCC surveillance is critical for early detection, especially in high-risk patients. However, long-term studies might be needed to further validate the results.
Keyphrases
- hepatitis b virus
- liver failure
- immune response
- end stage renal disease
- risk factors
- type diabetes
- sars cov
- public health
- newly diagnosed
- oxidative stress
- prognostic factors
- peritoneal dialysis
- squamous cell carcinoma
- inflammatory response
- dendritic cells
- single molecule
- weight loss
- physical activity
- weight gain
- molecular docking
- squamous cell