Glycine is a competitive antagonist of the TNF receptor mediating the expression of inflammatory cytokines in 3T3-L1 adipocytes.
Rodrigo Romero-NavaFrancisco J Alarcón-AguilarAbraham Giacoman-MartínezGerardo Blancas-FloresKarla A Aguayo-CerónMartha A Ballinas-VerdugoFausto Sánchez-MuñozFengyang HuangSantiago Villafaña-RaudaJulio Cesar Almanza-PérezPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)
These findings support the idea that glycine could partially inhibit the binding of TNF-α to its receptor and provide clues about the mechanisms by which glycine inhibits the secretion of pro-inflammatory adipokines in adipocytes through the TNF-α receptor.