Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms.
John T LeCarlos J Ballester-RosadoJames D FrostJohn W SwannPublished in: Epilepsia (2022)
Our EEG findings are the first to demonstrate progressive ictogenesis for epileptic spasms. Furthermore, in demonstrating cognitive deficits in the tetrodotoxin model, we have met a criterion for an animal model of West syndrome. Animal models will allow in-depth studies of spasm progression's potential role in cognitive regression and may elucidate why early treatment is considered essential for improved neurodevelopmental outcomes in children.