Increased thyroid uptake on 18F-FDG PET/CT is associated with the development of permanent hypothyroidism in stage IV melanoma patients treated with anti-PD-1 antibodies.
Alexandra FrelauXavier Palard-NovelloEva JaliLise BoussemartAlain DupuyPandora JamesAnne DevillersFlorence Le JeuneJulien EdelineThierry LesimpleAntoine GirardPublished in: Cancer immunology, immunotherapy : CII (2020)
SUVmax-Th > 4.1 and Th/B > 2.0 provided perfect diagnostic performances to detect patients that developed PTD. No significant survival difference was found between patients with and without increased thyroid uptake.