Genomic signature of parity in the breast of premenopausal women.
Julia Santucci-PereiraAnne Zeleniuch-JacquotteYelena AfanasyevaHua ZhongMichael SlifkerSuraj PeriEric A RossRicardo López de CiccoYubo ZhaiTheresa NguyenFathima SheriffIrma H RussoYanrong SuAlan A ArslanPal BordasPer LennerJanet ÅhmanAnna Stina Landström ErikssonRobert JohanssonGöran HallmansPaolo TonioloJose RussoPublished in: Breast cancer research : BCR (2019)
Genes transiently activated by FTP may have a role in protecting the mammary gland against neoplastically transformed cells through activation of T cells. Furthermore, chromatin remodeling and cell differentiation, represented by the genes that are maintained upregulated long after the FTP, may be responsible for the lasting preventive effect against breast cancer.
Keyphrases
- genome wide
- induced apoptosis
- breast cancer risk
- genome wide identification
- bioinformatics analysis
- cell cycle arrest
- copy number
- polycystic ovary syndrome
- transcription factor
- dna methylation
- gene expression
- dna damage
- postmenopausal women
- genome wide analysis
- endoplasmic reticulum stress
- oxidative stress
- cell death
- pregnant women
- cell proliferation
- childhood cancer