Glioblastoma-Infiltrating CD8+ T Cells Are Predominantly a Clonally Expanded GZMK+ Effector Population.
Anthony Z WangBryce L MashimoMaximilian O SchaettlerNgima D SherpaLydia A LeavittAlexandra J LivingstoneSaad M KhanMao LiMarkus I Anzaldua-CamposJoseph D BradleyEric C LeuthardtAlbert H KimJoshua L DowlingMichael R ChicoinePamela Stuart JonesBryan D ChoiDaniel P CahillBob S CarterAllegra A PettiTanner M JohannsGavin P DunnPublished in: Cancer discovery (2024)
To understand the limited efficacy of immune-checkpoint blockade in GBM, we applied a multiomics approach to understand the TIL landscape. By highlighting the enrichment of GZMK+ effector T cells and the lack of exhausted T cells, we provide a new potential mechanism of resistance to immunotherapy in GBM. This article is featured in Selected Articles from This Issue, p. 897.