Pyroptosis: a new paradigm of cell death for fighting against cancer.

Yixin TanQuanzhu ChenXiaoling LiZhaoyang ZengWei XiongGuiyuan LiXiayu LiJianbo YangBo XiangMei Yi

Published in: Journal of experimental & clinical cancer research : CR (2021)

In this review, we focus on the regulatory mechanisms of pyroptosis and the tumor suppressive function of pyroptosis. We discuss the attribution of pyroptosis in reprogramming tumor microenvironments and restoration of anti-tumor immunity and its potential application in cancer immune therapy.

Keyphrases

nlrp inflammasome
papillary thyroid
cell death
squamous cell
transcription factor
stem cells
lymph node metastasis
squamous cell carcinoma
signaling pathway
cell cycle arrest