Icos gene disruption in non-obese diabetic mice elicits myositis associated with anti-troponin T3 autoantibodies.

Gwladys BourdenetBaptiste PileyreLaurent DrouotJérémie MartinetChantal BécourtMarion CarretteGaétan RiouCécile BerguaThara JaworskiPhilippe ChanLaetitia JeanManuel FréretPascal CosetteChristian BoitardCatalina AbadOlivier Boyer

Published in: Neuropathology and applied neurobiology (2023)

NOD mice represent a spontaneous model of myositis and the discovery of anti-TNNT3 aAb suggests a new autoantigen in this model.

Keyphrases

interstitial lung disease
small molecule
metabolic syndrome
adipose tissue
systemic lupus erythematosus
weight loss
copy number
rheumatoid arthritis
gene expression
skeletal muscle
insulin resistance
dna methylation