The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis.
Antoine Fakhry AbdelMassihHala AghaSonia El-SaiediAmal El-SisiMeryam El ShershabyHanya GaberHabiba-Allah IsmailNadine El-HusseinyAbeer Reda AminAly ElBoraieAya AyadEsraa MenshaweyFady SefeinIbrahim Ihab OsmanMai MoursiMaram HanafyMariam Sherif AbdelazizMariem Badr ArsanyousMariam Khaled-Ibn-El-WalidMarwa Gamal TawfikMenna HabibMina Ehab MansourMirette AshrafMohamed Ayman KhattabNada AlshehryNada HafezNaheel Essam ElDeebNirvana AshrafNoha KhalilNoheir Ismail AbdElSalamNoura SheblNouran Gamal Ali HafezNourhan Hatem YoussefOdette BahnanPassant IsmailPeter KeladaRahma MenshaweyRana SaeedReem Jalal HusseinyReem YasserSafa SharafVeronia AdelYoustina NaeemYoustina Nagy Farid NicolaAya KamelRafeef HozaienRaghda FoudaPublished in: Bulletin of the National Research Centre (2022)
In conclusion, miRNAs are likely implicated in myocarditis associated with mRNA vaccines. Our hypothesis suggests the use of miRNA as a biomarker for the diagnosis of mRNA vaccine-induced myocarditis. Additionally, the interplay between viral miRNA and the host immune system could alter inflammatory profiles, hence suggesting the use of therapeutic inhibition to prevent such complications.