Association between mosaic loss of chromosome Y and pulmonary fibrosis susceptibility and severity.

Dapeng WangNiran HadadSamuel MossElena Lopez-JimenezSimon R JohnsonToby M MaherPhilip L MolyneauxYajie ZhaoJohn R B PerryPaul J WoltersJonathan A KropskiR Gisli JenkinsNicholas E BanovichIain Stewart

Published in: bioRxiv : the preprint server for biology (2024)

Our study confirms the existence of mLOY in PF patients and suggests that mLOY is not a major driver of IPF. The combined evidence suggests a triangulation model where telomere shortening leads to both IPF and mLOY.

Keyphrases

pulmonary fibrosis
end stage renal disease
idiopathic pulmonary fibrosis
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
prognostic factors
patient reported outcomes
gene expression
dna methylation
patient reported