The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn's disease.

Lumir KunovskyZ KalaF MarekJ DolinaK PoredskaL KucerovaK BenesovaL Mitas

Published in: International journal of colorectal disease (2018)

The group of operated patients with CD had a significantly higher distribution of at least one genetic mutation as opposed to the non-operated group. In patients with two or more mutations, the disease course was more aggressive. This group of patients might profit from the conservative top-down or early surgical therapy.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
genome wide
copy number
chronic kidney disease
peritoneal dialysis
prognostic factors
stem cells
patient reported outcomes
transcription factor
bone marrow
innate immune