Clonal hematopoiesis of indeterminate potential is associated with reduced risk of cognitive impairment in patients with chronic kidney disease.

Cissy XiaoManjula Kurella TamuraYang PanVarun RaoCelestin MissikpodeCaitlyn VlasschaertTetsushi NakaoXiao SunChangwei LiZhijie HuangAmanda AndersonMd Mesbah UddinDo-Kyun KimJonathan TaliercioRajat DeoZeenat BhatDawei XiePanduranga RaoJing ChenJames P LashJiang HePradeep NatarajanJames E HixsonKristine YaffeTanika N Kellynull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Our study is the first to examine the role of CHIP in cognitive decline in CKD. CHIP markedly decreased the risk of impairment in attention and executive function. CHIP was not associated with impairment in global cognition or verbal memory.

Keyphrases

cognitive decline
mild cognitive impairment
working memory
high throughput
circulating tumor cells
cognitive impairment
chronic kidney disease
multiple sclerosis
white matter
risk assessment
human health
climate change
fine needle aspiration