Macrophages reprogramming driven by cancer-associated fibroblasts under FOLFIRINOX treatment correlates with shorter survival in pancreatic cancer.

Zainab HussainThomas BertranPascal FinettiEugenie LohmannEmilie MamessierGhislain BidautFrançois BertucciMoacyr RegoRichard Tomasini

Published in: Cell communication and signaling : CCS (2024)

Our study provides insight into the complex interactions between TME cells under FOLFIRINOX treatment. It suggests potential novel candidates that could be used as therapeutic targets in combination with FOLFIRINOX to prevent and alleviate TME influx on therapeutic resistance as well as biomarkers to predict FOLFIRINOX response in PDAC patients. Video Abstract.

Keyphrases

locally advanced
end stage renal disease
induced apoptosis
ejection fraction
newly diagnosed
rectal cancer
peritoneal dialysis
prognostic factors
cell proliferation
combination therapy
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
extracellular matrix
replacement therapy
smoking cessation