Interplay between WNT/PI3K-mTOR axis and the microbiota in APC-driven colorectal carcinogenesis: data from a pilot study and possible implications for CRC prevention.

Floriana Jessica Di PaolaChiara AlquatiGabriele ContiGiulia CalafatoSilvia TurroniFederica D'AmicoClaudio CeccarelliFrancesco ButtittaAlice BernardiDajana CuicchiGilberto PoggioliDaniela TurchettiSimona FerrariRenato CannizzaroStefano RealdonPatrizia BrigidiLuigi Ricciardiello

Published in: Journal of translational medicine (2024)

Our study reveals an interplay between Wnt/β-catenin and PI3K/mTOR, whose derangement correlates with specific microbiota signatures in FAP and CRC patients, and identifies new potential biomarkers and targets to improve CRC prevention, early adenoma detection and treatment.

Keyphrases

cell proliferation
end stage renal disease
stem cells
ejection fraction
newly diagnosed
chronic kidney disease
genome wide
peritoneal dialysis
prognostic factors
machine learning
combination therapy
label free
smoking cessation
sensitive detection