Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.
Adan Pinto-FernandezMariolina SalioTom PartridgeJianzhou ChenGeorge VereHelene GreenwoodCyriel Sebastiaan OlieAndreas DamianouHannah Claire ScottHenry Jack PeggAlessandra ChiarenzaLaura Díaz-SaezPaul SmithClaudia Gonzalez-LopezBhavisha PatelEmma AndertonNeil JonesTim R HammondsKilian HuberRuth MuschelPersephone BorrowVincenzo CerundoloBenedikt M KesslerPublished in: British journal of cancer (2020)
Our results provide strong evidence for USP18 in regulating antigenicity and radiosensitivity, highlighting its potential as a cancer target.