Effect of Regorafenib on P2X7 Receptor Expression and Different Oncogenic Signaling Pathways in a Human Breast Cancer Cell Line: A Potential of New Insight of the Antitumor Effects of Regorafenib.

Muhammed M Salahuddin Gamal Abd El Hay OmranMaged W HelmyMaha E Houssen

Published in: Current issues in molecular biology (2021)

Regorafenib was demonstrated to possibly exhibit antitumor activity on the breast cancer cell line via modulation of the P2X7/HIF-1α/VEGF, P2X7/P38, P2X7/ERK/NF-κB, and P2X7/beclin 1 pathways.

Keyphrases

signaling pathway
endothelial cells
metastatic colorectal cancer
pi k akt
vascular endothelial growth factor
epithelial mesenchymal transition
cell proliferation
induced apoptosis
transcription factor
human health