Congenital human cytomegalovirus infection is associated with decreased transplacental IgG transfer efficiency due to maternal hypergammaglobulinemia.
Eleanor C SemmesShuk Hang LiJillian H HurstZidanyue YangDonna NiedzwieckiGenevieve G FoudaJoanne KurtzbergKyle M WalshSallie R PermarPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Our results indicate that cCMV infection moderately reduces transplacental IgG transfer efficiency due to maternal hypergammaglobulinemia; however, infants with and without cCMV infection had similar antigen-specific IgG levels, suggesting comparable protection from maternal IgG acquired via transplacental transfer.