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Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal-physiological function and against loperamide-induced constipation coupled to oxidative stress and inflammation in rats.

Najla HajjiDalanda WannesMohamed-Amine JabriKais RtibiHaifa TounsiAfifa AbdellaouiHichem Sebai
Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
GAAE showed a modest action against oxidative stress and decreased LOP effect and thereby can be considered a pharmacological agent in constipation.
Keyphrases
  • oxidative stress
  • diabetic rats
  • induced apoptosis
  • irritable bowel syndrome
  • dna damage
  • ischemia reperfusion injury
  • high glucose
  • ionic liquid
  • drug induced
  • endothelial cells
  • anti inflammatory
  • heat shock protein