IL-33 Signaling Inhibition Leads to a Preeclampsia-Like Phenotype in Pregnant Rats.
Xi WangCorbin A ShieldsDeanna ThompsonJie McKayRachel WilsonMarcus K RobbinsHannah GlennMolly FontenotJan M WilliamsDenise C CorneliusPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2024)
Data presented in this study demonstrate a role for IL-33 signaling in controlling vascular function and maternal blood pressure during pregnancy possibly by mediating innate and adaptive immune inflammatory responses, identifying the IL-33 signaling pathway as a potential therapeutic target for managing preeclampsia.
Keyphrases
- blood pressure
- signaling pathway
- early onset
- pregnancy outcomes
- immune response
- pregnant women
- electronic health record
- epithelial mesenchymal transition
- pi k akt
- heart rate
- oxidative stress
- hypertensive patients
- cell proliferation
- birth weight
- artificial intelligence
- blood glucose
- metabolic syndrome
- body mass index
- weight loss
- endoplasmic reticulum stress