E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension.

Dan Yi Bin LiuHongxu DingShuai LiRebecca LiJiakai PanKarina RamirezXiaomei XiaMrinalini KalaIndrapal SinghQinmao YeWon Hee LeeRichard E FryeTing WangYutong ZhaoKenneth S KnoxChristopher C GlembotskiMichael B FallonZhiyu Dai

Published in: bioRxiv : the preprint server for biology (2023)

Our study demonstrated that endothelial SOX17 deficiency induces PH through E2F1 and targeting E2F1 signaling represents a promising approach in PAH patients.

Keyphrases

pulmonary hypertension
end stage renal disease
stem cells
transcription factor
ejection fraction
newly diagnosed
prognostic factors
endothelial cells
high glucose
peritoneal dialysis
replacement therapy
pulmonary artery
oxidative stress
polycyclic aromatic hydrocarbons
stress induced