CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation.
Ryan Michael ReyesYilun DengDeyi ZhangNiannian JiNeelam MukherjeeKaren WheelerHarshita B GuptaAlvaro S PadronAravind KancharlaChenghao ZhangMyrna GarciaAnand V R KornepatiOnur BoymanJose R Conejo-GarciaRobert S SvatekTyler J CurielPublished in: Journal for immunotherapy of cancer (2021)
Mechanistic insights into differential IL-2c and αPD-L1 treatment and tissue-dependent effects could help develop rational combination treatment strategies to improve treatment efficacy in distinct cancers. These studies also provide insights into γδ T cell contributions to immunotherapy in bladder and engagement of adaptive immunity by IL-2c plus αPD-L1 to treat refractory lung metastases.