Evaluation of cytogenetic and molecular markers with MTX-mediated toxicity in pediatric acute lymphoblastic leukemia patients.
Ravi RamalingamHarpreet Kaur Satnam SinghJulius Xavier ScottLatha M SnehaGaneshprasad ArunkumarArathi SrinivasanSolomon F D PaulPublished in: Cancer chemotherapy and pharmacology (2022)
SLC19A1 facilitates the import of cyclic dinucleotides and reduced folates, evaluating genotypes in this gene can help in better management of patients on methotrexate treatment. Assessing a broader gene panel can help in finding more associated markers and delivering personalized medicine to the patients.
Keyphrases
- end stage renal disease
- acute lymphoblastic leukemia
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- genome wide
- dna methylation
- gene expression
- high dose
- low dose
- patient reported outcomes
- acute myeloid leukemia
- young adults
- single molecule
- allogeneic hematopoietic stem cell transplantation
- childhood cancer