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Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits.

Lei ChenQiang QiuYu JiangKun WangZeshan LinZhipeng LiFaysal BibiYongzhi YangJinhuan WangWenhui NieWeiting SuGuichun LiuQiye LiWeiwei FuXiangyu PanChang LiuJie YangChenzhou ZhangYuan YinYu WangYue ZhaoChen ZhangZhongkai WangYanli QinWei LiuBao WangYandong RenRu ZhangYan ZengRute R da FonsecaBin WeiRan LiWenting WanRuoping ZhaoWenbo ZhuYutao WangShengchang DuanYun GaoYong Edward ZhangChunyan ChenChristina HvilsomClinton W EppsLeona G ChemnickYang DongSiavash MirarabHans Redlef SiegismundOliver A RyderMarcus Thomas Pius GilbertHarris A LewinGuo-Jie ZhangRasmus HellerWen Wang
Published in: Science (New York, N.Y.) (2020)
The ruminants are one of the most successful mammalian lineages, exhibiting morphological and habitat diversity and containing several key livestock species. To better understand their evolution, we generated and analyzed de novo assembled genomes of 44 ruminant species, representing all six Ruminantia families. We used these genomes to create a time-calibrated phylogeny to resolve topological controversies, overcoming the challenges of incomplete lineage sorting. Population dynamic analyses show that population declines commenced between 100,000 and 50,000 years ago, which is concomitant with expansion in human populations. We also reveal genes and regulatory elements that possibly contribute to the evolution of the digestive system, cranial appendages, immune system, metabolism, body size, cursorial locomotion, and dentition of the ruminants.
Keyphrases
  • genome wide
  • single cell
  • endothelial cells
  • genetic diversity
  • climate change
  • dna methylation
  • transcription factor
  • induced pluripotent stem cells
  • cell fate