Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway.

Linsong TangShengjun XuRongli WeiGuanghan FanJunbin ZhouXuyong WeiXiao Xu

Published in: Molecular medicine (Cambridge, Mass.) (2024)

This study demonstrated that TCF7L2 promotes HCC metastasis by activating AKT/mTOR pathway in a NEDD9-dependent manner, suggesting that potential of TCF7L2 and NEDD9 as prognostic markers and therapeutic targets for HCC.

Keyphrases

signaling pathway
cell proliferation
transcription factor
pi k akt
epithelial mesenchymal transition
induced apoptosis
oxidative stress