Heterogeneous treatment effects of intensive glycemic control on kidney microvascular outcomes in ACCORD.

Vivek Charu Jane W Liang Glenn M ChertowZhuo Jun LiMaria E Montez-Rath Pascal GeldsetzerIan H de BoerLu Tian Manjula Kurella Tamura

Published in: medRxiv : the preprint server for health sciences (2023)

We found evidence of heterogenous treatment effects of intensive glycemic control on kidney microvascular outcomes in ACCORD as a function of predicted baseline risk of kidney failure. Patients with higher kidney failure risk experienced the most pronounced benefits of treatment on kidney microvascular outcomes but also experienced the highest risk of all-cause mortality.

Keyphrases

glycemic control
type diabetes
blood glucose
weight loss
combination therapy
metabolic syndrome
skeletal muscle