Mesenchymal Stem Cells May Alleviate the Intervertebral Disc Degeneration by Reducing the Oxidative Stress in Nucleus Pulposus Cells.
Yongzhao ZhaoQian XiangYunzhong ChengJialiang LinShuai JiangWei-Shi LiPublished in: Stem cells international (2022)
Stem cell therapy might repair the degenerative IVD via reducing the oxidative stress through the ceRNA regulatory work and restoration of autophagy in degenerative NPCs. This research could provide new insights into the mechanism research of stem cell therapy for IDD and potential therapeutic targets in the IDD treatment.
Keyphrases
- cell therapy
- oxidative stress
- induced apoptosis
- stem cells
- mesenchymal stem cells
- endoplasmic reticulum stress
- signaling pathway
- dna damage
- diabetic rats
- umbilical cord
- ischemia reperfusion injury
- cell cycle arrest
- cell death
- bone marrow
- long non coding rna
- risk assessment
- human health
- cell proliferation
- smoking cessation
- pi k akt