Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study.
Sally PeprahMartin D OgwangPatrick KerchanSteven J ReynoldsConstance N TengePamela A WereRobert T KuremuWalter N WekesaNestory MasaluEsther KawiraIsaac OtimIsmail D LegasonLeona W AyersKishor BhatiaJames J GoedertRuth M PfeifferSam M MbulaiteyePublished in: Infectious agents and cancer (2021)
Our study results reduce support for pre-enrollment antimalaria treatment as a sole explanation for the observed lower falciparum prevalence in eBL cases and open a space to consider alternative immunology-based hypotheses.