Microstructural alterations in the locus coeruleus-entorhinal cortex pathway in Alzheimer's disease and frontotemporal dementia.

Giulia QuattriniLorenzo PiniIlaria Boscolo GalazzoIleana O JelescuJorge JovicichRosa ManentiGiovanni B FrisoniMoira MarizzoniFrancesca B PizziniMichela Pievani

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)

Microstructural integrity of LC-TEC pathway is understudied in AD and bvFTD.LC-TEC microstructural alterations are present in both AD and bvFTD.Greater LC-TEC microstructural alterations in bvFTD than AD.LC-TEC microstructural alterations in bvFTD are associated to EC neurodegeneration.

Keyphrases

white matter
simultaneous determination
multiple sclerosis
mass spectrometry
liquid chromatography
cognitive decline
tandem mass spectrometry
high resolution
mild cognitive impairment