Zingiber officinale Ethanolic Extract Attenuated Reserpine-Induced Depression-Like Condition and Associated Hippocampal Aberrations in Experimental Wistar Rats.

Olanrewaju John Afees Joshua Oladele Owolabi Ifedamola Patience Awodein Joseph Igbo EnyaStephen Taiye AdelodunSunday Yinka OlatunjiSunday Oluwaseyi Fabiyi

Published in: Journal of experimental pharmacology (2020)

These findings showed structural and molecular alterations associated with reserpine-induced depression. Also, Zingiber officinale was effective to provide ameliorative and protective effects against the neurotoxic effects of reserpine in the hippocampus, making it a potential candidate for treating depression and its associated neurodegenerative diseases.

Keyphrases

depressive symptoms
high glucose
diabetic rats
sleep quality
oxidative stress
drug induced
cerebral ischemia
gene expression
dna methylation
copy number
risk assessment
physical activity
human health
genome wide
temporal lobe epilepsy