Passive and active immunity in infants born to mothers with SARS-CoV-2 infection during pregnancy: prospective cohort study.

Dongli SongMary PrahlStephanie L GawSudha Rani NarasimhanDaljeet S RaiAngela HuangClaudia V FloresChristine Y LinUnurzul JigmeddagvaAlan WuLakshmi WarrierJustine LevanCatherine B T NguyenPerri CallawayLila FarringtonGonzalo R AcevedoVeronica J GonzalezAnna VaabenPhuong NguyenElda AtmosferaConstance MarleauChristina AndersonSonya MisraMonica StemmleMaria CortesJennifer McAuleyNicole MetzRupalee PatelMatthew NudelmanSusan AbrahamJames ByrnePriya Jegatheesan

Published in: BMJ open (2021)

Maternal SARS-CoV-2 IgG is efficiently transferred across the placenta when infections occur more than 2 months before delivery. Maternally derived passive immunity may persist in infants up to 6 months of life. Neonates are capable of mounting a strong antibody response to perinatal SARS-CoV-2 infection.

Keyphrases

respiratory syndrome coronavirus
sars cov
low birth weight
birth weight
coronavirus disease
gestational age
pregnant women
preterm birth
body mass index
physical activity