Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas.

Anne-Sophie Sertier Anthony Ferrari Roxane M Pommier Isabelle Treilleux Sandrine Boyault Mojgan Devouassoux-Shisheboran Janice Kielbassa Emilie Thomas Laurie Tonon Vincent Le Texier Amandine Charreton Anne-Pierre Morel Anne Floquet Florence Joly Lobbedez Dominique Berton-Rigaud Gwenaël Ferron Laurent Arnould Sabrina Croce Guillaume Bataillon Pierre Saintigny Eliane Mery-Lamarche Christine Sagan Aruni P Senaratne Ivo Glynne Gut Fabien Calvo Alain Viari Maria Ouzounova Isabelle L Ray-Coquard Alain Puisieux

Published in: Cancer research communications (2023)

We have provided a detailed characterization of the genomic landscape of CS and identified EMT as a common mechanism associated with phenotypic divergence, linking CS heterogeneity to genetic, transcriptomic, and epigenetic influences.

Keyphrases

single cell
rna seq
copy number
dna methylation
epithelial mesenchymal transition
genome wide