New daily persistent headache after SARS-CoV-2 infection: a report of two cases.

Fedele DonoStefano ConsoliGiacomo EvangelistaMaria D'ApolitoMirella RussoClaudia CarrariniDario CalisiMatteo De RosaMartina Di PietroMaria Vittoria De AngelisDaniela TravagliniStefano L SensiMarco OnofrjLaura Bonanni

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2021)

Our report described two cases of probable NDPH due to SARS-CoV-2 infection. Clinical evaluation of COVID-19 patients presenting with persistent headache should take into consideration NDPH. Given the supposed major role for neuroinflammation in the genesis of Sars-CoV-2-driven NDPH, immunomodulatory therapy should be promptly started. In line with this hypothesis, we obtained a good therapeutic response to short-term high dose of corticosteroids.

Keyphrases

sars cov
respiratory syndrome coronavirus
high dose
coronavirus disease
low dose
traumatic brain injury
stem cell transplantation
lipopolysaccharide induced
physical activity
cognitive impairment
lps induced
stem cells
bone marrow
cerebral ischemia
replacement therapy