Calretinin Staining in Anorectal Line Biopsies Accurately Distinguished Hirschsprung Disease in a Retrospective Study.
Suzanna J LoganHong YinBeverly RogersNicoleta ArvaMiriam R ConcesSandy Cope-YokoyamaLouis P DehnerCarlos GallianiShipra GargMai HeAliya N HusainMatthew KeislingChandra KrishnanElena PuscasiuChristopher RossiFaiza SiddiquiLisa SuttonJefferson TerryAmeet I ThakerYuan HuangJie ZhangCourtney McCrackenHeather RyttingPublished in: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (2022)
Absence of calretinin positive mucosal neurites at the anorectal line was highly accurate in distinguishing Hirschsprung disease from non Hirschsprung disease cases in this blinded retrospective study. Calretinin staining is useful for interpreting biopsies from the physiologic hypoganglionic zone up to the anorectal line.
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