Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms.
Clemens SchafmayerJames William HarrisonStephan BuchChristina LangeMatthias C ReichertPhilipp HoferFrançois CossaisJuozas KupcinskasWitigo von SchönfelsBodo SchniewindWolfgang KruisJürgen TepelMyrko ZobelJonas RosendahlThorsten JacobiAndreas Walther-BerendsMichael SchroederIlka VogelPetr SergeevHans BoedekerHolger HinrichsenAndreas VolkJens-Uwe ErkGreta BurmeisterAlexander HendricksSebastian HinzSebastian WolffMartina BöttnerAndrew R WoodJessica TyrrellRobin N BeaumontMelanie LangheinrichTorsten KucharzikStefanie BrezinaUrsula Huber-SchönauerLeonora PietschLaura Sophie NoackMario BroschAlexander HerrmannRaghavan Veera ThangapandiHans Wolfgang SchimmingSebastian ZeissigStefan PalmGerd FockeAnna AndreassonPeter T SchmidtJuergen WeitzMichael KrawczakHenry VölzkeGernot LeebPatrick MichlWolfgang LiebRobert GrützmannAndre FrankeFrank LammertThomas BeckerLimas KupcinskasMauro D'AmatoThilo WedelChristian DatzAndrea GsurMichael N WeedonJochen HampePublished in: Gut (2019)
In silico analyses point to diverticulosis primarily as a disorder of intestinal neuromuscular function and of impaired connective fibre support, while an additional diverticulitis risk might be conferred by epithelial dysfunction.
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