Diffuse Midline Glioma Invasion and Metastasis Rely on Cell-autonomous Signaling.
Marco BruschiLilia MidjekYassine AjlilStephanie VairyManon LancienSamia GhermaouiThomas KergrohenMaïté VerreaultAhmed IdbaïhCarlos Alberto Oliveira de BiagiIlon LiuMariella G FilbinKévin BeccariaThomas BlauwblommeStephanie PugetArnault Tauziede-EspariatPascale VarletVolodia Dangouloff-RosNathalie BoddaertGwenael Le TeuffJacques GrillGuillaume MontagnacNadia ElkhatibMarie-Anne DebilyDavid CastelPublished in: Neuro-oncology (2023)
Our findings identify two new therapeutic avenues. First, patient-derived GSCs represent a predictive tool for patient stratification in order to adapt irradiation strategies. Second, autocrine and short-range BMP7-related signaling becomes a druggable target to prevent DMG spread and metastasis.