Extending the phenotypic spectrum assessed by the CDR plus NACC FTLD in genetic frontotemporal dementia.
Kiran SamraGeorgia PeakmanAmy M MacDougallArabella BouziguesCaroline V GreavesRhian S ConveryJohn C van SwietenLize JiskootHarro SeelaarFermin MorenoRaquel Sanchez-ValleRobert LaforceCaroline GraffMario MasellisMaria Carmela TartagliaJames B RoweBarbara BorroniElizabeth FingerMatthis SynofzikDaniela GalimbertiRik VandenbergheAlexandre de MendonçaChris R ButlerAlexander GerhardSimon DucharmeIsabelle Le BerPietro TiraboschiIsabel SantanaFlorence PasquierJohannes LevinMarkus OttoSandro SorbiJonathan Daniel RohrerLucy L Russellnull nullPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)
The new Clinical Dementia Rating Dementia Staging Instrument plus National Alzheimer's Coordinating Center Behavior and Language Domains neuropsychiatric and motor (CDR plus NACC FTLD-NM) rating scale was significantly positively correlated with the original CDR plus NACC FTLD and negatively correlated with the FTD Rating Scale (FRS).No participants with a clinical diagnosis in the frontotemporal dementia spectrum were classified as asymptomatic with the new CDR plus NACC FTLD-NM rating scale.Individuals had higher global severity scores with the addition of the neuropsychiatric and motor domains.A receiver operating characteristic analysis of symptomatic diagnosis showed nominally higher areas under the curve for the new scales.