Polymorphisms and avascular necrosis in patients with sickle cell disease - A systematic review.
Márcio Passos LeandroNatália Damasceno AlmeidaLara Santana HocevarCloud Kennedy Couto de SáAmâncio José de SouzaMarcos Antônio Almeida MatosPublished in: Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo (2022)
The results indicate that the polymorphisms in BMP6, Klotho and ANXA2 genes may be associated with avascular necrosis in patients with sickle cell disease. However, in order to confirm these genetic changes as risk factors, further studies with greater statistical power and methodological rigor are needed.