Nanoscale reorganization of synaptic proteins in Alzheimer's disease.

Wang-Hui ZhuXiao-Xu YangXu-Zhuo GouShu-Mei FuJia-Hui ChenFeng GaoYong ShenDan-Lei BiAi-Hui Tang

Published in: Neuropathology and applied neurobiology (2023)

Our study revealed a spatiotemporal-specific reorganization of synaptic nanostructures in AD and identifies dense-core amyloid plaques as the major local inductor in APP23 mice.

Keyphrases

prefrontal cortex
genome wide
single cell
high fat diet induced
type diabetes
gene expression
skeletal muscle
insulin resistance