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The Effect of KSK-94, a Dual Histamine H 3 and Sigma-2 Receptor Ligand, on Adipose Tissue in a Rat Model of Developing Obesity.

Magdalena KotańskaMonika ZadrożnaMonika KubackaKamil MikaKatarzyna SzczepańskaBarbara NowakAlessio AlesciAnthea MillerEugenia Rita LaurianoKatarzyna Kieć-Kononowicz
Published in: Pharmaceuticals (Basel, Switzerland) (2024)
receptor and, to a lesser extent, sigma-2 receptor, could be attractive therapeutic options for patients at risk of developing obesity or with obesity and some metabolic disorders. However, more studies are required to determine its safety profile and the exact mechanism of action of KSK-94.
Keyphrases
  • insulin resistance
  • metabolic syndrome
  • adipose tissue
  • weight loss
  • type diabetes
  • high fat diet induced
  • weight gain
  • high fat diet
  • body mass index
  • density functional theory
  • physical activity
  • case control